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Nuedexta is a unique medication that combines two drugs, dextromethorphan hydrobromide and quinidine sulfate, to treat PBA.

However, recent studies suggest that Nuedexta may have broader applications for other neurological and psychological conditions such as Alzheimer’s disease, autism spectrum disorder, and depression.


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Nuedexta is a prescription medication that contains a combination of two active ingredients, dextromethorphan hydrobromide and quinidine sulfate. It was first approved by the U.S Food and Drug Administration (FDA) in 2010 to treat pseudobulbar affect (PBA), a condition characterized by uncontrollable and frequent outbursts of laughing or crying that are unrelated to the person’s actual emotional state. PBA often affects people with various neurological conditions such as Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease.

Dextromethorphan hydrobromide is a cough suppressant that works by blocking the N-methyl-D-aspartate (NMDA) receptors in the brain. It is classified as an NMDA receptor antagonist and is known to have some mild dissociative effects. On the other hand, quinidine sulfate is a medication that is typically used to treat heart conditions such as arrhythmia. In dextromethorphan , quinidine sulfate is used in a small amount to inhibit the enzyme that metabolizes dextromethorphan, resulting in increased levels of dextromethorphan in the body. The combination of the two drugs in Nuedexta is thought to help reduce the symptoms of PBA by regulating the neurotransmitters that are involved in emotional responses.

Apart from its approved use for PBA, recent studies have shown that dextromethorphan has potential benefits for other neurological and psychological conditions. One study published in The Journal of Clinical Psychiatry in 2017 found that Nuedexta was effective in reducing agitation and aggression in patients with Alzheimer’s disease. Another study published in the Journal of Neurology, Neurosurgery, & Psychiatry in 2019 found that improved certain aspects of social cognition and emotional processing in patients with autism spectrum disorder.

Moreover, there is some preliminary evidence to suggest that may be beneficial for treating depression. One study published in the American Journal of Psychiatry in 2019 found that dextromethorphan was effective in reducing depressive symptoms in patients with bipolar disorder who were also experiencing PBA. While further studies are needed to confirm these findings, they suggest that may have broader applications beyond its original indication for PBA.

Like any medication, Nuedexta has potential side effects. The most common side effects that have been reported include diarrhea, dizziness, cough, vomiting, weakness, and urinary tract infection. In rare cases, more serious side effects such as arrhythmia, QT prolongation, and thrombocytopenia may occur. It is important to discuss any potential side effects with your doctor before starting dextromethorphan .

Additionally, Nuedexta is not recommended for use in patients with certain medical conditions, such as heart problems, liver disease, or a history of blood clots. It is also not recommended for use in pregnant or breastfeeding women. Nuedexta may interact with other medications, particularly those that affect the heart, and it is important to inform your doctor of all medications you are currently taking.

In conclusion, While there are potential side effects and medical precautions to be aware of, Nuedexta offers a promising treatment option for those who suffer from PBA and other related conditions. If you or a loved one suffers from PBA or other neurological or psychological conditions, talk to your doctor about whether Nuedexta may be an appropriate treatment option.

nuedexta indication

Nuedexta is a medication prescribed to patients suffering from pseudobulbar affect (PBA), a neurological condition that causes uncontrollable and unpredictable outbursts of laughter or tears. PBA can occur in patients with various underlying neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and stroke.

Nuedexta is the first and only medication approved by the FDA specifically for the treatment of PBA. It contains a combination of dextromethorphan, a cough suppressant, and quinidine, a medication used to treat heart rhythm disorders. The combination of these two medications works in the brain to reduce involuntary laughing or crying episodes in PBA patients.

Nuedexta is available in capsules and should be taken as directed by a healthcare provider. Patients should be monitored for any potential side effects, including dizziness, diarrhea, vomiting, and dry mouth.

Nuedexta has shown significant improvement in reducing the number and severity of PBA episodes in clinical studies. Patients who have taken Nuedexta have reported improved quality of life, increased social activities, and less anxiety and embarrassment related to PBA.

If you or someone you know is experiencing symptoms of PBA, talk to a healthcare provider about Nuedexta. It is an effective treatment option that can help improve the quality of life for those suffering from this neurological condition.

1 review for Nuedexta

  1. Mary Belinda

    Mi esposo fue diagnosticado con la enfermedad de Parkinson hace 2 años, cuando tenía 59 años. Tenía una postura encorvada, temblores, el brazo derecho no se mueve y también una sensación pulsante en su cuerpo. Recibió Senemet durante 8 meses y luego se introdujo Siferol y reemplazó a Senemet, durante este lapso de tiempo también se le diagnosticó demencia. Empezó a tener alucinaciones, perdió el contacto. Sospechando que era el medicamento, le quité el Siferol (con el conocimiento del médico), lo tomó con la fórmula de hierbas naturales PD que ordenamos de TREE OF LIFE HEALTH CLINIC, sus síntomas disminuyeron por completo durante 3 semanas de uso de TREE OF LIFE HEALTH Enfermedad de Parkinson natural fórmula a base de hierbas. Ahora tiene casi 61 años y está muy bien, ¡la enfermedad se revirtió por completo!

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